ATP – Communicable Diseases Research

ATP enhances the error-prone ribonucleotide incorporation by the SARS-CoV-2 RNA polymerase

Article

Published on 2022-10-152022-11-15
Journal: Biochemical and Biophysical Research Communication
[Category] COVID19(2023년), SARS, 치료제,

Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro

Article

Published on 2022-10-012022-11-15
Journal: Antiviral Research
[Category] COVID19(2023년), SARS, 치료제,

State-of-the-Art Molecular Dynamics Simulation Studies of RNA-Dependent RNA Polymerase of SARS-CoV-2

Article

Published on 2022-09-082022-11-15
Journal: International Journal of Molecular Sciences
[Category] SARS, 치료제,

Alterations in CD39/CD73 axis of T cells associated with COVID-19 severity

COVID-19 중증도와 관련된 T 세포의 CD39/CD73 축 변경

Article

Published on 2022-08-012022-09-11
Journal: Journal of cellular physiology
[Category] MERS, 바이오마커, 진단,

[키워드] Activation adenosine adenosine triphosphate alteration Annexin Apoptosis ATP Blood CD25 CD27 CD28 CD4 CD73 CD8 Cell collected controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokines decrease effector cell expression Extracellular Frequency healthy controls healthy donor immune function Immunopathogenesis immunopathology in vitro Inflammation involved knowledge memory T mild COVID-19 patient mild COVID-19 patients modulate Monocytes mononuclear cell nuclear pathway patients PD-1 Peripheral blood plasma samples Purinergic purines purines. reduced Regulation Regulatory Regulatory T cell SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severity Signaling T cell T cells T lymphocytes T-cell These data triphosphate Viral viral infections with COVID-19
[DOI] 10.1002/jcp.30805 PMC 바로가기 [Article Type] Article

In silico study indicates antimalarials as direct inhibitors of SARS-CoV-2-RNA dependent RNA polymerase

In silico 연구는 항말라리아제가 SARS-CoV-2-RNA 의존성 RNA 중합효소의 직접적인 억제제임을 나타냅니다.

Article

Published on 2022-08-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 치료제,

[키워드] active site active sites acute respiratory syndrome coronavirus Amino acid amino acid residue amino acid residues amodiaquine antimalarial Antimalarials Antiviral ATP binding caused Chloroquine co-crystallized Compound conserved coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 crystal structure docked docking results global pandemic Hydroxychloroquine in silico in silico inhibition. indicate inhibitor interactions involved MD simulation molecular pandemic PDB PDB ID performed Poliovirus RdRP RdRps Remdesivir Replication researcher residue residues respiratory RNA RNA dependent RNA polymerase RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2-RNA dependent RNA polymerase screened Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation study Structure suggested Superimposition Transcription Treatment was used
[DOI] 10.1080/07391102.2021.1871956 PMC 바로가기 [Article Type] Article

Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation

Research

Published on 2022-07-282022-10-05
Journal: ISME Communications
[Category] 변종, 유전자 메커니즘,

Targeting ACLY efficiently inhibits SARS-CoV-2 replication

ACLY를 표적으로 SARS-CoV-2 복제를 효율적으로 억제

Article

Published on 2022-07-112022-09-11
Journal: International Journal of Biological Sciences
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACLY acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses Analysis ATP caused citrate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Delta Factor help Host identify in vitro in vivo inhibit Intervention involved metabolome metabolomic metabolomics metabolomics. Mutation omicron pandemic public health replication of SARS-CoV-2 required SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus susceptibility targeting targets Therapeutics Transmissibility Treatment Vaccine variants variants of concern virulence virus replication VOCs wild-type
[DOI] 10.7150/ijbs.72709 PMC 바로가기 [Article Type] Article

A Path-Based Analysis of Infected Cell Line and COVID-19 Patient Transcriptome Reveals Novel Potential Targets and Drugs Against SARS-CoV-2

감염된 세포주 및 COVID-19 환자 전사체의 경로 기반 분석을 통해 SARS-CoV-2에 대한 새로운 잠재적 표적 및 약물 공개

Article

Published on 2022-07-012022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ADCY2 ADSL Against anti-SARS-CoV-2 ATP bemcentinib biological network BUB1 Cell cell line cell lines central gene central genes changes Concordance conivaptan COVID-19 COVID-19 severity curated DEGs DEGs (Differentially Expressed Genes) Differentially expressed genes drug drugs targeting dysregulated e genes G1/S transition Genes greater identify Infection leukocyte leukocyte activation LINE metabolic process Migration MOST network analysis novel OCRL PBK PBMC PBMCs PBMCs (Peripheral Blood Mononuclear Cells) peripheral Peripheral blood Peripheral blood mononuclear cells phthalocyanine Potential reveal SARS-C0V-2 SARS-CoV-2 SARS-COV-2 infection severity target target gene TIAM1 Transcriptome Transcriptome. transcriptomic viruses with COVID-19
[DOI] 10.3389/fimmu.2022.918817 PMC 바로가기 [Article Type] Article

Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study

코로나 이후 증상 치료를 위한 관점 식품 보충제로서의 발효 카리카 파파야 및 모린다 시트리폴리아: 무작위 위약 대조 임상 실험실 연구

Randomized Controlled Trial

Published on 2022-05-252022-09-11
Journal: Nutrients
[Category] COVID19(2023년), SARS, 변종, 임상,

[키워드] added addition alleviate Anti-inflammatory effects antioxidant antioxidant activity ATP Carica papaya clinical clinical laboratory clinical symptom Clinical symptoms computer tomography COVID-19 disease cytokine Cytokines delta variant disease Electrocardiography expression fermented food supplements food IL-17A IL-6 IL-8 immune Laboratory leukocyte long-lasting mechanisms metabolite microbiota Moderate COVID-19 modulating Morinda citrifolia Nitrate nitrates nitrates/nitrites nitric oxide nitrite nitrites omicron oral-nasal-pharyngeal microbiota participant Patient per day performed phagocyte phagocytosis physical physical endurance placebo group placebo-controlled polymorphonuclear leukocyte post-COVID symptoms pro-inflammatory cytokines pro-inflammatory cytokines. questionnaire Randomized significantly single-center Symptoms the placebo group Treatment protocol tropical variant virus were assessed
[DOI] 10.3390/nu14112203 PMC 바로가기 [Article Type] Randomized Controlled Trial

Possible role of pannexin 1 channels and purinergic receptors in the pathogenesis and mechanism of action of SARS-CoV-2 and therapeutic potential of targeting them in COVID-19

Review

Published on 2022-03-112023-07-01
Journal: Life sciences
[Category] COVID19(2023년), SARS,

[키워드] ATP COVID-19 Drug repurposing Pannexins purinergic receptors SARS-CoV-2
[DOI] 10.1016/j.lfs.2022.120482 PMC 바로가기 [Article Type] Review